mugen_edamame: (Default)
waddapp blud

タンパクの代謝

ケトン対合性
in the absence of sugar brain uses ketones as energy source

重要酵素
acc, fas

重要転写調節因子
ChREBP, SREBP1c, LXR

脂肪酸の分解と合成は同時に行われない

摂食t時にACCによりmaroniruCoAができるとCPT1が阻害されて脂肪酸がmitoに入れない

to prevent waste of energy of uncontrolled fatty acid formation n breakdown

脂肪酸合成センサー
絶食や運動でAMPKが活性化されて、ACC不活性化され、maroniruCoAが減少され、CPT1が活性化し、分解が促進

お酒を飲むと
アルコール分解でNADHが産生される
糖新生が阻害され低血糖に。
ラーメン美味しい!!!
脂肪酸が分解されず、合成される

cholesterol is fucking important in the production of hormones






コレステロール
胆汁酸、ステロイドホルモン、ビタミンD
脳では神経伸長に重要
皮膚の保温に重要
コレステロール、脂質合成系に核内受容体は重要
PPAR, LXR, SREBO, PGC-1, FXR

えぜちみぶha小腸のコレステロールトランスポーターに作用し、コレステロールの吸収を選択的に阻害

スタチンはコレステロール合成を阻害

SHP regulate SREBP1c expression via LRH-1 and LXR

LDL, HDL, VLDL

リポタンパク質
apoB, apoaI, apoE
コレステロールの引き抜き

LDL (sticks to walls of blood vessels, thickens them) and VLDL (plaque deposits on artery walls) is not good for u

HDL is v good for u (HDL travels w apoA1 protein and together they scrape the bad cholesterol off the walls yoooo) (apoB drops off the shitty cholesterols so fuck apoB)




mugen_edamame: (Default)
 midterm
chapter 1
http://health-science-labo.com/newsletter/pdf/khsnewsletter_vol.1.pdf

antiaging

Food
eat up to seventy per cent full, caloric restriction improves metabolism, increases longevity
サーチュイン gene activated w caloric restriction
the gene can 老化やがんの原因となる過 剰な活性酸素の害が取り除かれ、免疫力の向上、高血糖や動脈 硬化の抑制、脳機能の活性化
in mouse tests only works for male mice

caloric restriction helps make u more active and look younger, but also
心疾患やがんの発症が自由摂食 群の半分で、糖尿病はゼロ

shit that helps w metabolism can be found in foodz
赤ワインのレスベラトロール、リンゴの ケルセチン、お茶のエピガロカテキンガレートといった抗酸 化成分、ビタミンB3など
レスベラトロール increases rate of metabolism while asleep, lowers blood pressure, eases plaque in vessel
mitochondria output improves




Exercise
fifteen minutes exercise a day reduces risk of death by fourteen percent, the more you exercise, the better
one fifty mins a week at medium intensity would be good
high intensity, risk of death further lowers.

Heart
Being positive increases longevity, lowers risk of heart disease
Mentally stimulating lifestyle reduces risk of alzheimers
ポジティブな人には心臓病が少ない
βアミロイドが脳内に蓄積されte, contributes to alzheimers
mentally active, less B amyloid
ネプリライシン breaks down B amyloid, seen to decrease w progression of brain degeneration, but remains at fourty per cent higher 


chapter 3
http://health-science-labo.com/newsletter_member/pdf/khsnewsletter_vol.3.pdf
脳と心の健康



chapter 5
http://health-science-labo.com/newsletter_member/pdf/khsnewsletter_vol.5.pdf
よい眠り

chapter 7
http://health-science-labo.com/newsletter_member/pdf/khsnewsletter_vol.7.pdf
高血圧 動脈硬化

chapter 9
http://health-science-labo.com/newsletter_member/pdf/khsnewsletter_vol.9.pdf
circadian rhythm

chapter 11
http://health-science-labo.com/newsletter_member/pdf/khsnewsletter_vol.11.pdf
健康の鍵を握る

chapter 13
http://health-science-labo.com/newsletter_member/pdf/khsnewsletter_vol.13.pdf
オーラルヘルス

mugen_edamame: (Default)
 安全 vs 安心

anzen is safety  リスクを受容できるまで抑えた状態
anshin is peace of mind  安全を実現している人、組織への信頼

言い張る  insist

金銭  きんせん  Money, cash



脂肪酸燃焼
マラソンなどの長距離走
熊の冬眠
渡り鳥
ラクダのこぶ。水分を脂肪分解で得ている

どうして脂肪をためるのか
疎水性で軽量である
そすいせい hydrophobic

ケトン体合性
脳みそ can only consume glucose
if glucose runs out 糖新生 happens where amino acid gets turned to sugar
水溶性
v water soluble
bad fr u





mugen_edamame: (Default)
第一段階

 タンパク質 to アミノ酸
多糖類 to 単糖類
脂肪 to 脂肪酸、glycerol

第二段階
アミノ酸、単糖、脂肪酸、->Acetyl CoA

glucoseの場合は解答!!!という過程で。cytosol で進行し酸素はいらない
for this process only lil bit of ATP and NADH made
sudden burst of energy, not v good conversion to energy rate but you don't need supply of oxygen

400m is about the limit of glycolysis burst speed, which makes it the hardest distance to run

第三段階
Acetyl coA完全に酸化されてand you get water and CO2. この過程はすべてmitochondria内で




glycolysis 

NADH is like a traveler's check???





r







TCA cycle
pyruvic acid to acetyl co A

Carbons lost as CO2 x 2
基質レベルのリン酸化でGTpが1分子生成

NADHが3分子生成

FDH2が1分子生成






too much glyycogen and it's stored as fat
脂質 can only become fat
and fat can't become sugar
though sugar can become fat
タンパク質 can become fat and also sugar







mugen_edamame: (Default)
 代謝divided into 2
異化 catabolism   energy you get from breaking down food and shit
and
同化 anabolism energy used up to make shit like cells and shit 

eg plant takes in water carbon dioxide etc to grow is 同化

plant releasing CO2 and 02 from respiration and chlorophyll shit is 異化

body made from cells yeahhahhahh

組織の中で適切に働くように細胞は分化している

転写 transcription
翻訳 translation

consumes energy to make RNA, to make Protein (which needs energy and bits 酵素 enzyme)
rnaが遺伝情報とタンパク質合成の仲立ちとなる
energy taken from food, and stored in easy to use ATP form

enzymes catalyse breaking down of shit, and chain of stuff happening is called METABOLIC PATHWAY

aside from atp u also can get energy in forms of gtp, fadhs nadh2 and nadph2

but atp is most commonly used



y do we need energy buddiezz
nucleotideの伸長、ribosomeにおける翻訳など、細胞の中でおこるあらゆる反応にはenergyが必要
典型的なものは筋肉の收縮

呼吸鎖
biggest producer of AtP (was it?)

many different pathways for ATP w varying levels of efficacy
but some are anaerobic, which is their selling point 解糖系 glycolysis

有酸素運動 aerobic activity
good for health because it burns 脂質
anaerobic (sudden and intense) does not draw from fat
無酸素運動 can help you through about 400 meters before it goes fuck off to hell m8 i need a break

glucose gets converted to energy better than pocari
fructose is harder to convert to energy 取り出しにくい
and fructose 蓄積 more easily stored than burned, can instead make you gain weight, accumulates in oily form a lot

shit that matters for ATP production
mitochondria 
and cytosol

MITOCHONDRIA IS THE POWERHOUSE OF THE CELL
外膜、内膜、基質、クリステ
連続的に千篇をなんちゃらなんちゃら

発エルゴン反応is 異化反応
An exergonic process is one in which there is a positive flow of energy from the system to the surroundings. 
酵素helps process go through (activation energy 活性化エネルギー)

吸エルゴン反応is同化反応
means "absorbing energy in the form of work." Endergonic reactions are not spontaneous

共役反応
coupled reaction
そこでエネルギーを供給(kyoukyuu,supplyする反応を共役させて、エネルギー収支をあわせる

エネルギー供給分子
adenosine triphosphate

breaking down of atp to adp releases useable energy

in glycolysis, glucose is converted to glyceraldehyde 3 phosphate and then to pyruvate, nett gain of 2 ATP, is anaerobic

nadph
fadh2



coEnzymeA
補酵素coA
脂肪を蓄積
lipids as they are cant be broken down for energy
so coA breaks them down so that they can be catalysed



電子の運搬








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mugen_edamame: (Default)
Yu, or Mu

September 2015

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